Using description logics to evaluate the consistency of drug-class membership relations in NDF-RT
نویسندگان
چکیده
منابع مشابه
Using description logics to evaluate the consistency of drug-class membership relations in NDF-RT
BACKGROUND The NDF-RT (National Drug File Reference Terminology) is an ontology, which describes drugs and their properties and supports computerized physician order entry systems. NDF-RT's classes are mostly specified using only necessary conditions and lack sufficient conditions, making its use limited until recently, when asserted drug-class relations were added. The addition of these assert...
متن کاملEvaluating the consistency of inferred drug-class membership re- lations in NDF-RT
Objectives: To evaluate the consistency of inferred drugclass membership relations in NDF-RT (National Drug File Reference Terminology). Methods: We use an OWL reasoner to infer the drug-class membership relations from the class definitions and the descriptions of drugs and compare them to asserted relations. Results: The inferred and asserted relations only match in about 50% of the cases. Con...
متن کاملPharmGKB Drug Data Normalization with NDF-RT
The Pharmacogenomics Knowledge Base (PharmGKB) [1] is a publicly available central resource for pharmacogenomics data and knowledge, which is being widely employed into clinical practice and thus requires using clinical terminologies. Hence, harmonizing PharmGKB drug data with well annotated drug terminologies will facilitate its integration with other related resources and support data represe...
متن کاملEvaluating drug-drug interaction information in NDF-RT and DrugBank
BACKGROUND There is limited consensus among drug information sources on what constitutes drug-drug interactions (DDIs). We investigate DDI information in two publicly available sources, NDF-RT and DrugBank. METHODS We acquire drug-drug interactions from NDF-RT and DrugBank, and normalize the drugs to RxNorm. We compare interactions between NDF-RT and DrugBank and evaluate both sources against...
متن کاملUsing Description Logics for Consistency-based Diagnosis
Using quantitative models of simple mechanisms as an example domain, we show how the basic principles of consistency-based diagnosis can be implemented using description logics with expressive concrete domains. In addition, description logics provide the inference services necessary to organize and validate model libraries, an aspect that is neglected in consistency-based diagnosis until now. 1...
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ژورنال
عنوان ژورنال: Journal of Biomedical Semantics
سال: 2015
ISSN: 2041-1480
DOI: 10.1186/s13326-015-0007-3